Cigarette Smoke Radicals and the Role of Free Radicals in Chemical Carcinogenicity
نویسندگان
چکیده
منابع مشابه
Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity.
This article consists of two parts: a brief overview of the ways in which free radicals can be involved in chemical carcinogenesis, and a review of cigarette smoke chemistry. Carcinogenesis is generally agreed to involve at least three stages: initiation, promotion, and progression. It is suggested that radicals sometimes are involved in the initiation step, either in the oxidative activation o...
متن کاملInvestigation of Free Radicals in Cigarette Mainstream Smoke
Electron Paramagnetic Resonance spectroscopy (EPR) coupled with spin trapping methodology has been used to study the formation of free radicals in mainstream cigarette smoke. Kentucky reference cigarettes (2R4F) were smoked using a 20-port smok ing machine (Borgwaldt-kc) under ISO smoking conditions. Free radicals in both particulate phase and gas phase smoke were analysed. Short-lived Cand O-...
متن کاملSpin Trapping of Radicals in Gas-Phase Cigarette Smoke
Since the spin trapping technique was developed and utilized to determine radicals in the gas phase (see reviews [1—3]), it has become attractive as a method of detecting radicals in gas-phase tobacco smoke. A first study of this sort was reported by Bluhm et al. in 1971 [4], while previous studies were forced to rely on the measurements of smoke condensate at liquid nitrogen temperature [5, 6]...
متن کاملA protocol for detecting and scavenging gas-phase free radicals in mainstream cigarette smoke.
Cigarette smoking is associated with human cancers. It has been reported that most of the lung cancer deaths are caused by cigarette smoking (5,6,7,12). Although tobacco tars and related products in the particle phase of cigarette smoke are major causes of carcinogenic and mutagenic related diseases, cigarette smoke contains significant amounts of free radicals that are also considered as an i...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1997
ISSN: 0091-6765
DOI: 10.2307/3433297